Physical fitness – Open Door Youth Center http://opendooryouthcenter.org/ Mon, 18 Oct 2021 17:13:57 +0000 en-US hourly 1 https://wordpress.org/?v=5.8 http://opendooryouthcenter.org/wp-content/uploads/2021/10/icon-8.png Physical fitness – Open Door Youth Center http://opendooryouthcenter.org/ 32 32 ‘Fat can be in shape’: fitness rather than weight loss should be the main goal, study finds http://opendooryouthcenter.org/fat-can-be-in-shape-fitness-rather-than-weight-loss-should-be-the-main-goal-study-finds/ http://opendooryouthcenter.org/fat-can-be-in-shape-fitness-rather-than-weight-loss-should-be-the-main-goal-study-finds/#respond Wed, 22 Sep 2021 07:00:00 +0000 http://opendooryouthcenter.org/fat-can-be-in-shape-fitness-rather-than-weight-loss-should-be-the-main-goal-study-finds/ When it comes to health, the focus is on weight loss and body mass index (BMI). Research focused on weight loss may find correlations with a lower risk of death, but a new article suggests more emphasis should be placed on physical activity rather than weight loss. Shifting the goal of weight loss might make […]]]>

When it comes to health, the focus is on weight loss and body mass index (BMI). Research focused on weight loss may find correlations with a lower risk of death, but a new article suggests more emphasis should be placed on physical activity rather than weight loss.

Shifting the goal of weight loss might make more sense for people who are obese and want to be healthier.

“We’d like people to know that fat can get fit, and that fit and healthy bodies come in all shapes and sizes,” said Glenn Gaesser, co-author of the College of Health Solutions article. from Arizona State University in a Press release. “We realize that in a culture obsessed with weight, it can be difficult for programs that aren’t focused on weight loss to gain traction. We are not necessarily against weight loss; we just think that shouldn’t be the primary yardstick for judging the success of a lifestyle intervention program.

In an article published in iScience, researchers are looking at data from several studies looking at weight loss or physical activity, or a combination of the two. They propose a weight-neutral approach, because a diet focused on cardiorespiratory fitness or physical activity reduces or eliminates the risk of obesity-related mortality. They define weight neutral as not focused on weight loss.

The authors write: “The 40-year trends in the prevalence of obesity and weight loss attempts indicate that a weight-centered focus on the treatment of obesity has been largely ineffective.

Regular exercise also improves cardiometabolic health, and this occurs regardless of weight loss.

By separating health from weight loss, experts believe it would be a more effective way to improve health and reduce risks for obese people.

“This is especially important when considering the physiological realities of obesity,” says co-author Siddhartha Angadi of the School of Education and Human Development at the University of Virginia in the press release. “Body weight is a highly inherited trait, and weight loss is associated with substantial metabolic changes that ultimately thwart the maintenance of weight loss.”


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One problem when it comes to studying this area of ​​health is that some previous studies rely on epidemiological studies that cannot determine the causes of obesity. These types of studies collect different types of data that can be correlated with body weight, genetic factors, or obesity. To fully examine a fitness-based approach to getting bodies to a healthy place would require randomized clinical trials with control groups and treatment groups, much like what is done to test new drugs.

This group of researchers analyzed several of these studies to combine the data so that they could attempt to draw broader conclusions.

“Collectively, however, these epidemiological studies demonstrate strong and consistent associations, and that is why meta-analyzes can be useful,” Angadi said in the press release. “In the case of physical activity and fitness, the epidemiological evidence is supported by a large number of experimental studies and randomized controlled trials which have established plausible mechanisms for consistent results of epidemiological studies.”

The authors of the article point out that recent fitness research suggests that focusing on physical activity and cardiorespiratory fitness reliably leads to a greater reduction in the risk of death and heart disease. A study they cited found that in a study that followed people with coronary artery disease for more than 15 years, people who maintained at least low physical activity had a 19% lower risk of all-cause mortality. that of similar sedentary people. People with high physical activity performed even better with a 36% lower risk of death. The authors also suggest that maintaining a physically active lifestyle may be more achievable than maintaining weight loss.


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Fitness vs physical activity – Sooke News Mirror http://opendooryouthcenter.org/fitness-vs-physical-activity-sooke-news-mirror/ http://opendooryouthcenter.org/fitness-vs-physical-activity-sooke-news-mirror/#respond Mon, 13 Sep 2021 07:00:00 +0000 http://opendooryouthcenter.org/fitness-vs-physical-activity-sooke-news-mirror/ How Much Physical Activity Is Enough? How much exercise do we need to improve our health compared to how much exercise do we need to achieve optimal physical shape? Do Optimal Fitness Levels Directly Correlate with Optimal Health? The truth is, we haven’t spent a lot of time researching these questions. Generally speaking, the intensity […]]]>

How Much Physical Activity Is Enough? How much exercise do we need to improve our health compared to how much exercise do we need to achieve optimal physical shape? Do Optimal Fitness Levels Directly Correlate with Optimal Health?

The truth is, we haven’t spent a lot of time researching these questions.

Generally speaking, the intensity and frequency of physical activity follow the law of diminishing returns. Simply put, you put in a little bit of effort, you get big benefits. If you put in a lot of effort – record hard workouts, you will improve even more, but not to the same degree.

Here’s a hypothetical trainee: Average height and weight A 50-year-old walks three times a week for 30 minutes. They achieve a moderate level of fitness and maintain a reasonable level of fat, but not the physique of the Sports Illustrated Swimsuit. Suppose the same person increases their workouts to a 45 minute brisk walk / jog three times a week and twice a week while doing yoga and weights. In this case, they will improve their fitness considerably – but not as much as the person who goes from a total sedentary lifestyle to 30 minutes of brisk walking three times a week.

The best value for money is getting a moderate amount of exercise compared to double the amount of this workout.

Older people who try to work out to very high exercise volumes with higher intensity will greatly increase the risk of injury. The simple rule to follow is not to increase the duration or intensity by more than five percent every two weeks if there is no muscle soreness. So a 30-minute brisk walk changes to 32 minutes, then 34, and so on.

A recent study of data from the Framingham Heart Study looked at data from 2,000 subjects. The new review concluded that light exercise such as leisurely walking was not as effective as vigorous exercise in improving health. Specifically, vigorous exercise was three times more effective than moderate walking and 14 times more effective than simply reducing the time spent being less sedentary.

A second result is that those who recorded the highest level of daily steps at a vigorous level were able to compensate for the negative impact of being sedentary at other times of the day – think of the office worker who remains seated. eight hours a day and only goes to the gym 45 minutes a day. Despite the imbalance, the fitness program can partially offset the negative impact of being largely sedentary.

The review of the Framingham study seems to contradict what I said at the outset. I agree that increasing the intensity and duration of the exercise will make a big difference and that a sweaty walk is better than a walk. The study did not examine what it takes for a sedentary person to significantly improve their health, not just their fitness.

So, if you are a couch keeper, rest assured that levitating your butt off that couch and doing a brisk walk for 20 minutes will make a huge difference to your well-being, both physically and mentally. Start easy, and the hardest part is just that: getting started. Once you’ve been on a beginner’s program for a few months, you’re ready to work a lot harder.

•••

Ron Cain is the owner of Sooke Mobile Personal Training. Email him at sookepersonaltraining@gmail.com or find him on Facebook at Sooke Personal Training.


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Watch Miss Hawaii USA Crash The Navy Fitness Test http://opendooryouthcenter.org/watch-miss-hawaii-usa-crash-the-navy-fitness-test/ http://opendooryouthcenter.org/watch-miss-hawaii-usa-crash-the-navy-fitness-test/#respond Mon, 06 Sep 2021 07:00:00 +0000 http://opendooryouthcenter.org/watch-miss-hawaii-usa-crash-the-navy-fitness-test/ In the latest video on his YouTube channel, Navy veteran and fitness influencer Austen Alexander invites performance coach Samantha Neyland and 2019 Miss Hawaii USA to take the US Navy physical readiness test. The PRT has recently been reorganized and Ashley Sepulveda of the Navy joins Alexander and Neyland to act as overseer during the […]]]>

In the latest video on his YouTube channel, Navy veteran and fitness influencer Austen Alexander invites performance coach Samantha Neyland and 2019 Miss Hawaii USA to take the US Navy physical readiness test. The PRT has recently been reorganized and Ashley Sepulveda of the Navy joins Alexander and Neyland to act as overseer during the challenge.

“My goal today is just to finish the whole test and finish with a good attitude,” said Neyland.

The first PRT event is 2 minutes of push-ups. Exhibiting proper technique is important here: Full arm extension is required at the upper end of the repetition, with the elbows bending to a 90 degree angle at the lower end. After just 1 minute and 25 reps, however, Sepulveda must end the test as Neyland lets his knees contact the ground for a fraction of a second.

Next, Neyland has to hold a forearm plank for as long as she can. The plank is a newly introduced part of the test, having replaced the sit-up part. Neyland lasts 1 minute 48 seconds before her form collapses and she crumbles to the ground.

The third and final component of the PRT is a 1.5 mile race, consisting of 6 total laps around the track, which Neyland manages to complete in 13:48, showing exemplary sprinting form towards the end, even beating Alexander up to the finish line.

“Since they changed the Navy PRT, especially since I came out in November, I don’t know the standards,” says Alexander. “I expect she might have done good to averages in the push-ups, maybe the board is okay or maybe good bass, and in the run I think she did good averages or good bass. “

Sepulveda calculates that Neyland obtained an overall score of “good low”, which counts as a pass for a female military member of her age group. “Dude, this is harder than you think,” said Neyland after completing the entire test. “It’s definitely harder than you think. Everything Austen tells you is easy, don’t worry, it’s okay, run away!”

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COVID 19 fitness and immunity study is connected / Public Information Service http://opendooryouthcenter.org/covid-19-fitness-and-immunity-study-is-connected-public-information-service/ http://opendooryouthcenter.org/covid-19-fitness-and-immunity-study-is-connected-public-information-service/#respond Fri, 13 Aug 2021 07:00:00 +0000 http://opendooryouthcenter.org/covid-19-fitness-and-immunity-study-is-connected-public-information-service/ ALBUQUERQUE, NM – A researcher at the University of New Mexico wants to know if exercise is helping fight COVID and is recruiting people to help it. Michael Deyhle, assistant professor in the Department of Health, Exercise, and Athletic Sciences at the University of New Mexico, will investigate whether exercise habits or fitness levels give […]]]>

ALBUQUERQUE, NM – A researcher at the University of New Mexico wants to know if exercise is helping fight COVID and is recruiting people to help it.

Michael Deyhle, assistant professor in the Department of Health, Exercise, and Athletic Sciences at the University of New Mexico, will investigate whether exercise habits or fitness levels give vaccinated people more immunity. against the coronavirus.

It is looking for at least 60 participants between the ages of 18 and 65 who received the Pfizer or Moderna mRNA vaccines in the past six months.

Deyhle said some studies have shown that physical activity can produce beneficial antibodies, and that’s the question he wants to answer.

“Does being in good physical shape or physically active improve your immune response or improve how your immune system works when you get the vaccine, so that you are more protected in the future if you have to meet them?” ? Deyhle wondered.

Deyhle stressed that study participants will be asked about their physical activity and will undergo aerobic capacity and muscle strength tests. They will also have their body fat percentage measured and provide a blood sample to determine the concentration of antibodies produced from the vaccine.

Deyhle believes that vaccination is one of the most effective interventions in modern medicine to save lives, but he noted that its effectiveness may depend on age, genetic factors and other variables.

“Everyone reacts differently to vaccination,” warned Deyhle. “And some people have a very good response and a very robust response and some people just don’t respond as well, and there are a lot of factors that can account for this variability.”

He added that studies on some vaccines have shown that exercise can improve the body’s immune response, but there is no definitive work on whether this applies to COVID-19 vaccines.

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Marine Corps PFT eliminating creaks from planks during physical fitness test http://opendooryouthcenter.org/marine-corps-pft-eliminating-creaks-from-planks-during-physical-fitness-test/ http://opendooryouthcenter.org/marine-corps-pft-eliminating-creaks-from-planks-during-physical-fitness-test/#respond Tue, 10 Aug 2021 07:00:00 +0000 http://opendooryouthcenter.org/marine-corps-pft-eliminating-creaks-from-planks-during-physical-fitness-test/ The Marine Corps will eliminate crunches from its fitness test in favor of boards by 2023, according to a Navy administrative message released Thursday. “The isometric plank grip requires constant muscle activation, engages almost twice as many muscles as crunch, and is reliable in measuring midsection endurance required for military tasks and activities of daily […]]]>

The Marine Corps will eliminate crunches from its fitness test in favor of boards by 2023, according to a Navy administrative message released Thursday.

“The isometric plank grip requires constant muscle activation, engages almost twice as many muscles as crunch, and is reliable in measuring midsection endurance required for military tasks and activities of daily living,” said wrote Lt. Gen. Lewis Craparotta, commanding general of Corps Training and Education Command, in the message announcing the changes.

Sometimes referred to as a forward grip, a plank is a core isometric exercise that involves maintaining a push-up-like position while resting your body weight on the forearms or hands.

In response to feedback from the Marines, the Corps added the plank to its 2020 fitness test as an alternative to crunches, with a minimum wait time of 1 minute, three seconds needed to pass, and a wait time of 4 minutes, 20 seconds considered a perfect score. But starting Jan. 1, 2022, the Corps will modify those requirements slightly by increasing the minimum to 1 minute 10 seconds and lowering the maximum to 3 minutes 45 seconds, according to the post. The board will become the new standard in 2023.

“As of January 1, 2023, planking will be mandatory for PFT and abdominal tightening will no longer be an alternative to planking,” the post said. “This MARADMIN serves as an advance notice to ensure the Marines have sufficient time to train and prepare for the plank event prior to the CY 2023 policy change.”

The updated Marine Corps physical and combat readiness testing ordinance is expected to be released before the end of 2021, according to a Marine spokesperson.

As an instructional video from the Quantico Marine Corps Base explains, the planks will need to be performed on a flat surface and the Marines will begin in a push-up position with feet hip-width apart and toes extended. Once they rest their weight on their forearms and hands, “the back, buttocks and legs should be straight from head to heels,” says a marine narrator, “and should remain so throughout. test”.

US Marine Corps 1st Lt. Philip Sartain (left), a field artillery officer, with Battery C, 1st Battalion, 11th Marine Regiment, 1st Marine Division, and Warrant Officer Tanner L. Grace (right) , a weapons repair officer, with 1st Battalion, 11th Marine Regiment, 1st Marine Division, perform an exercise during a high-intensity interval training session at Marine Corps Base Camp Pendleton, Calif., on March 12, 2021. Chris Hinshaw, an elite athletic trainer, conducted training sessions and health talks with participants to enable them to appropriately train their assigned Marines to achieve optimal combat readiness. (U.S. Marine Corps photo by Lance Cpl. Quince Bisard)

Individual physical training representatives will monitor no more than seven Marines as they conduct the exercise and will call 15-second intervals until completion, according to Major Lindsey Slyman of the Human Performance Branch of the Marine Corps. Time will be called if a Marine falls to the ground, raises his or her feet or hands, or fails to maintain a straight line with their body, although a verbal warning is permitted.

“For decades, the Marine Corps has used crunches to improve and assess abdominal endurance,” said Captain Sam Stephenson, spokesperson for the Marines. “However, research has shown that crunches with the feet restrained require significant activation of the hip flexors. This has been linked to an increased risk of injury, including lower back pain due to increased lumbar lordosis.”

“Sailors are less likely to sustain injury or fatigue during functional tasks such as hiking, lifting and crawling,” added Stephenson.

Indeed, a research paper sent to the Commander of the Navy in 2018 noted that lower back pain was the “primary” musculoskeletal diagnosis treated at clinics at Camp Lejeune, North Carolina, between 2017 and 2018. , as reported by the Marine Corps Times. The crunch was “ineffective in assessing the functional strength of the core” and “arguably detrimental to the health of the back,” the newspaper said. In contrast, the plank exercise was shown to “relieve pressure on the lower back” and received high marks among Sailors participating in a 2012 study of the Navy Fitness Test.

Brian McGuire, a retired Marine Colonel who now heads the Marine Corps Human Performance Branch, believes the change of the board will help make Marines healthier and stronger.

“After years of doing crunches, what we now know is that crunches with the feet restrained require a lot of hip flexor activation, and this has been linked to an increased risk of injury, especially back pain due to repetitive lumbar flexion, ”McGuire said. Task and objective. “Isometric hold of the board requires constant muscle activation, engages almost twice as many muscles as crunch, and is reliable as a measure of midsection endurance required for military tasks.”

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Loss of smell, poor physical condition associated with cognitive impairment following COVID-19 infection http://opendooryouthcenter.org/loss-of-smell-poor-physical-condition-associated-with-cognitive-impairment-following-covid-19-infection/ http://opendooryouthcenter.org/loss-of-smell-poor-physical-condition-associated-with-cognitive-impairment-following-covid-19-infection/#respond Mon, 09 Aug 2021 07:00:00 +0000 http://opendooryouthcenter.org/loss-of-smell-poor-physical-condition-associated-with-cognitive-impairment-following-covid-19-infection/ Research presented at the Alzheimer’s Association (AAIC) 2021 International Conference found associations between COVID-19 and persistent cognitive deficits, including the pathology and symptoms of Alzheimer’s disease. According to investigators, cognitive impairment was also found to correlate with persistent loss of smell in recovered COVID-19 patients. “These new data point to disturbing trends showing COVID-19 infections […]]]>

Research presented at the Alzheimer’s Association (AAIC) 2021 International Conference found associations between COVID-19 and persistent cognitive deficits, including the pathology and symptoms of Alzheimer’s disease. According to investigators, cognitive impairment was also found to correlate with persistent loss of smell in recovered COVID-19 patients.

“These new data point to disturbing trends showing COVID-19 infections leading to lasting cognitive impairment and even Alzheimer’s symptoms,” said Heather M. Snyder, PhD, vice president of medical and scientific relations at Alzheimer’s Association, in a press release. “With more than 180 million cases and nearly 4 million deaths worldwide, COVID-19 has devastated the whole world. It is imperative that we continue to study what this virus is doing to our bodies and brains. The Alzheimer’s Association and its partners are at the forefront, but more research is needed.

In addition to the respiratory and gastrointestinal complications associated with COVID-19, many patients experience short- and / or long-term neuropsychiatric symptoms, including loss of smell and taste, and cognitive and speech deficits. attention, commonly referred to as “brain fog”.

For some patients, these neurological symptoms are persistent. Researchers are currently working to understand the mechanisms behind the cognitive dysfunction caused by SARS-CoV-2 and what this might mean for the long-term cognitive health of these patients.

Researchers assessed the cognition and olfactory senses of a cohort of nearly 300 elderly people with COVID-19. Participants were observed between 3 and 6 months after infection with COVID-19.

More than half of the study participants had persistent problems with forgetting. Additionally, 1 in 4 patients had additional cognitive problems, including language and executive dysfunction. These difficulties were associated with persistent smell problems, regardless of the severity of the original symptoms of COVID-19.

“We are starting to see clear links between COVID-19 and cognitive issues months after infection,” said Gabriel de Erausquin, MD, PhD, MSc, in the statement. “It is imperative that we continue to study this population, and others around the world, for a longer period of time to better understand the long-term neurological impacts of COVID-19. “

It was also found by a separate study that people who recovered from COVID-19 and experienced cognitive decline were more likely to be in poor physical condition and have lower oxygen saturation. Investigators analyzed cognitive impairment and associated health measures in 32 previously hospitalized patients who had mild to moderate COVID-19 2 months after discharge from hospital.

According to the researchers, the lower cognitive test scores for these patients were associated with higher age, waist circumference, and waist-to-hip ratio. Additionally, after adjusting for age and gender, lower memory and thinking scores were independently associated with lower levels of oxygen saturation during the 6-minute walk test, a measure commonly used to assess ability. function of people with cardiopulmonary disease.

“An oxygen-deprived brain is not healthy, and persistent deprivation may very well contribute to cognitive difficulties,” George Vavougios, MD, PhD, postdoctoral researcher for the University of Thessaly, said in the statement. “These data suggest some common biological mechanisms between the dyscognitive spectrum of COVID-19 and post-COVID-19 fatigue that have been reported anecdotally in recent months. “

REFERENCE

COVID-19 associated with long-term cognitive dysfunction, acceleration of Alzheimer’s symptoms [news release]. AICA; July 29, 2021. Accessed August 5, 2021.


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U.S. Marine Corps fitness test drops crunches for boards http://opendooryouthcenter.org/u-s-marine-corps-fitness-test-drops-crunches-for-boards/ http://opendooryouthcenter.org/u-s-marine-corps-fitness-test-drops-crunches-for-boards/#respond Fri, 06 Aug 2021 07:00:00 +0000 http://opendooryouthcenter.org/u-s-marine-corps-fitness-test-drops-crunches-for-boards/ Members of the United States Marine Corps will no longer be forced to pump themselves rep after rep of crunches when they undertake the famous branch physical fitness test (PFT). Exercise will be abandoned altogether in favor of the plank as the new standard for assessing core strength and fitness, according to Task and objective. […]]]>

Members of the United States Marine Corps will no longer be forced to pump themselves rep after rep of crunches when they undertake the famous branch physical fitness test (PFT). Exercise will be abandoned altogether in favor of the plank as the new standard for assessing core strength and fitness, according to Task and objective. The board was first introduced to the PFT as an alternative to crunches in 2020, which means that participants can currently choose to take either the crunches or the planks for their test. The PFT also includes pull-ups or push-ups and a three-mile timed run.

The switch to boards will not happen overnight. The direction to change the test, which came from an administrative message authorized by Lt. Gen. Lewis A. Craparotta, who serves as the commanding general, Training and Education Command, indicates that the plank will become the core exercise mandatory in 2023. The delay in completely dropping crunches gives Marines and recruits enough time to train and prepare for the board.

The standards to be passed for the exercise will drop in 2022 to a wait of 1 minute and 10 seconds at the bottom of the scale (compared to 1 minute and 3 seconds currently) and a wait of 3 minutes and 45 seconds to reach the maximum score. . (compared to the current 4 minutes and 20 seconds).

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This modification of the test was not made on a whim. Planks were added after research showed crunches were not the best way to gauge the physical readiness the Body needed – and potentially put you in a potentially risky position. “For decades, the Marine Corps has used crunches to improve and assess abdominal endurance,” states an article published by the Marines Human Performance Office. “However, research has shown that crunches with rested feet require significant activation of the hip flexors. This has been linked to an increased risk of injury, including lower back pain from increased lumbar lordosis.”

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Additionally, the brass at USMC found the board to be a better test for their needs. “Isometric holding of the board requires constant muscle activation, activates almost twice as many muscles as crunching, and has been shown to be the most reliable in measuring the true endurance required for daily activity function,” the release said. “With increased base strength, Marines are less likely to sustain injury or fatigue from functional tasks such as hiking, lifting and crawling.”

It’s a smart move by the USMC, but remember you might have different goals for your boards than a member of the Marines. As they train for this very specific endurance test, most people probably use planks in their workouts to build strength and stability and to sculpt their abs. For best results, you should probably aim for the lower USMC score and hold the plank position for about a minute at a time. Instead of aiming for marathon holds, focus on keeping your muscles engaged and your body in a perfect position to get the most out of the movement.

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Appleton Terror Twilight Track Meet Held To Safely Promote Fitness and Community Engagement | WFRV Local 5 http://opendooryouthcenter.org/appleton-terror-twilight-track-meet-held-to-safely-promote-fitness-and-community-engagement-wfrv-local-5/ http://opendooryouthcenter.org/appleton-terror-twilight-track-meet-held-to-safely-promote-fitness-and-community-engagement-wfrv-local-5/#respond Thu, 05 Aug 2021 07:00:00 +0000 http://opendooryouthcenter.org/appleton-terror-twilight-track-meet-held-to-safely-promote-fitness-and-community-engagement-wfrv-local-5/ APPLETON, Wisconsin (WFRV) – Make it to the Olympics, the folks at Appleton West High School are giving you bang for your buck. Ex-packer Jimmy Graham says he was “essentially forced” to get vaccinated On Wednesday, Local 5 watched in amazement as community members of all ages and skill levels come together at Terror Twilight […]]]>

APPLETON, Wisconsin (WFRV) – Make it to the Olympics, the folks at Appleton West High School are giving you bang for your buck.

On Wednesday, Local 5 watched in amazement as community members of all ages and skill levels come together at Terror Twilight Track’s 3rd Annual Gathering for a friendly and fun competition promoting both the safe physical fitness and community engagement.

Principal of Appleton West High School, Mark McQuade, who enthusiastically participated in the event, said: “We really encourage the community to come together, have a healthy way of having fun and celebrating a bit. ”

The Terror Twilight had all the intensity and thrill of watching events one would normally see in a track and field competition, including the 50-meter sprint, 100-meter sprint, 400-meter sprint, the 400 meter relay, the 1600 meter relay, shot put, long jump, high jump, 1 mile run and fun run for kids.

During the events, the participants not only enjoyed running laps, but between laps they also had the chance to catch up and hang out with old friends and peers. “I have enjoyed my four years at Appleton West and seeing people from the past is always a great feeling,” said Appleton West alumnus Carter Feiler.


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Key protein linked to both fitness in young people and diseases of old age http://opendooryouthcenter.org/key-protein-linked-to-both-fitness-in-young-people-and-diseases-of-old-age/ http://opendooryouthcenter.org/key-protein-linked-to-both-fitness-in-young-people-and-diseases-of-old-age/#respond Wed, 04 Aug 2021 07:00:00 +0000 http://opendooryouthcenter.org/key-protein-linked-to-both-fitness-in-young-people-and-diseases-of-old-age/ Researchers at Johns Hopkins Medicine say they have added evidence that a protein called CaMKII improves strength, endurance, muscle health and fitness in young animals. Their experiments with mice and fruit flies, however, revealed that the CaMKII gene also contributes to an evolutionary trade-off: increased susceptibility to diseases associated with age, frailty and mortality. The […]]]>

Researchers at Johns Hopkins Medicine say they have added evidence that a protein called CaMKII improves strength, endurance, muscle health and fitness in young animals. Their experiments with mice and fruit flies, however, revealed that the CaMKII gene also contributes to an evolutionary trade-off: increased susceptibility to diseases associated with age, frailty and mortality.

The research, published May 26 in Nature Communication, indicates that future therapies targeting CaMKII could prevent diseases of old age, say investigators.

The evolutionary conservation of genes that allow young people to run faster and respond robustly to fight-or-flight responses makes sense, according to study leaders: it helps them catch prey or escape predators, thus ensuring their reproductive success. However, some of these genes come at a high price that animals have to pay as they get older.

The new research shows that activating CaMKII via a chemical reaction caused by the addition of oxygen, known as oxidation, enhances these survival responses for young animals. However, oxidative stress increases with aging, which leads to excessive activation of CaMKII. Elevated CaMKII activity has long been linked to tissue damage seen in heart failure, atrial fibrillation, cancer, pulmonary and neurodegenerative diseases, according to study co-leader Mark Anderson MD, Ph.D. , Professor of Medicine and Head of the Department of Medicine at Johns Hopkins University School of Medicine.

In an effort to further explore oxidative stress and its links to aging and fitness, Anderson and his research team genetically engineered mice to make their CaMKII resistant to oxidation. They then used mouse-sized treadmills to compare the athletic performance of mice with and without CaMKII oxidation.

They found that mice with oxidized CaMKII were able to run, on average, about 150 meters further and about 5 meters per minute faster than mice with oxidation resistant CaMKII.

When researchers biopsied muscle tissue from mice and looked for other genes previously linked to muscle growth, post-exercise recovery, improved blood flow, and immune cell activation – factors that increase physical endurance – they found them activated only in mice with oxidizable CaMKII.

Further experiments showed that CaMKII activity in mouse muscle tissue increased the expression of cellular pathways related to inflammation, diabetes, cardiac enlargement, seizures and obesity.

These experiences are further evidence that the diseases of aging are natural compromises built into our genetic makeup, says Qinchuan Wang, Ph.D., co-director and assistant professor of medicine at Johns Hopkins University School of Medicine. “But they give us some hope that it is possible to target this genetic architecture to fight age-related diseases.”

The Johns Hopkins medical team also performed experiments on genetically engineered fruit flies to see if an oxidizable CaMKII produced similar performance and health effects in invertebrates, which do not naturally have a sensitive CaMKII protein. to oxidation.

The researchers used a gene cutter and insert tool called CRISPR to add the oxidation site to the CaMKII gene in fruit fly DNA.

In one experiment, the flies were placed in glass tubes and allowed to climb to the top of the tube. The researchers found that flies genetically engineered to have oxidizable CaMKII soared higher and 5 mm per second faster than flies with oxidation-resistant CaMKII. The result suggests that a physiological level of oxidative stress can improve physical performance by oxidizing and activating CaMKII.

When the researchers fed the flies an antioxidant diet to negate the effects of oxidative stress on the modified CaMKII, flies with and without the genetic modification had similar results in the escalation test.

In another experiment, the researchers fed the flies a diet containing the herbicide paraquat, which overloads the flies with excess oxidants that activate CaMKII only in genetically modified flies, but not unmodified flies. They found that the climbing performance of flies with the oxidant resistant CaMKII gene was not affected by the paraquat diet, which was expected since there is no protein to activate.

In contrast, under such oxidative stress, flies genetically modified with oxidizable CaMKII experienced a significant reduction in their climbing performance: they climbed almost 10 mm per second slower than their counterparts fed a normal diet, which which suggests that excessive oxidative stress results in physical decline through oxidation. and activation of CaMKII.

The researchers made similar observations in the hearts of flies. They found that the hearts of flies with oxidizable CaMKII contracted more strongly and relaxed faster than flies with oxidation resistant CaMKII. However, the performance benefit of the hearts of genetically engineered flies was reversed when the researchers neutralized the oxidants with an antioxidant. The researchers also found that the hearts of genetically engineered flies are more vulnerable to the damaging effects of an excess of oxidant, as they either became dysfunctional or stopped beating altogether when treated with paraquat, the generating chemical. oxidizer.

The most striking finding, Wang says, was that despite better physical performance and better heart function, genetically engineered flies experienced faster age-related decline and died at a younger age.

One of the main roles of evolution is to improve the ability to perpetuate the species, including producing more offspring and being able to find food. Our results claim that improving the longevity or lifespan of a species is not always necessary for this to happen. In fact, some of the very adaptations that make a species successful also contribute to aging and the diseases associated with age. “

Gabriel Bever, Ph.D., associate professor of functional anatomy and evolution in the Johns Hopkins University School of Medicine and study collaborator

Overall, the researchers say these findings may provide new targets for treating diseases linked to an abundance of oxidative damage and may also explain why studies of broad-spectrum antioxidants, such as vitamins C and E, have has shown mixed results in the treatment of heart disease, Parkinson’s disease and Huntington’s disease.

Scientists say that designing treatments specifically targeting gene regulators such as CaMKII may work better.

“For hundreds of millions of years, these diseases have been programmed into animal genomes to torment us at the end of our lives,” says Bever. “It is obvious that we need a more complete understanding of their evolutionary roots if we ever hope to find cures.”

Researchers have found additional evidence that CaMKII activates genes associated with early immune responses, an adaptation of early vertebrates that confers fitness by helping prevent infectious disease. Scientists have found that as people age, abnormal activation of the immune system contributes to systemic and chronic inflammation and increases the risk of all major age-related diseases. “The ability of CaMKII to activate the immune response to oxidative stress may hold the key to its involvement in aging and disease,” explains Wang.

Source:

Journal reference:

Wang, Q., et al. (2021) The oxidation of CaMKII is a performance / critical disease compromise acquired at the dawn of vertebrate evolution. Natural communications. doi.org/10.1038/s41467-021-23549-3.


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Sunil Sharma instills fitness habits in people with DFT CrossFit Sports Gym http://opendooryouthcenter.org/sunil-sharma-instills-fitness-habits-in-people-with-dft-crossfit-sports-gym/ http://opendooryouthcenter.org/sunil-sharma-instills-fitness-habits-in-people-with-dft-crossfit-sports-gym/#respond Tue, 03 Aug 2021 08:33:00 +0000 http://opendooryouthcenter.org/sunil-sharma-instills-fitness-habits-in-people-with-dft-crossfit-sports-gym/ Success is not imminent. It is an arduous process that can take a significant portion of one’s life. Persistence adds fuel to this never-ending desire for success and shapes results your way. Sunil Sharma is a success story that has established itself as a fitness brand with perseverance. By the age of 28, most people […]]]>

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